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High anti-oxidation power

Active oxygen removal effect, antioxidant capacity evaluation by β-carotene discoloring method, etc.

Fullerene is known for its high antioxidant capacity that has been confirmed in various experiments. A typical example is the test result of "172-fold of Vitamin C".
This has been found by β-carotene discoloring method, which is one of the methods used for the evaluation of the antioxidant capacity. With the β-carotene discoloring method, various active oxygen sources are given to β-carotene which initially exhibits yellow color in an aqueous solution and discolors by the addition of the active oxygen sources, and an antioxidant is added to the test group in order to evaluate the antioxidant’s capacity based on the extent to which the discoloring rate can be suppressed.

In this way, when the antioxidant capacity of the water-soluble fullerene material Radical Sponge® and that of vitamin C were compared, Fullerene's anti oxidative ability is 172 times more effective than vitamin C.

Similarly, fullerene has also been confirmed to exhibit an even effect against typical active oxygen sources (lipid radicals, hydrogen peroxide, and superoxide radicals). In this test, when fullerene was compared against other typical antioxidants (vitamin C derivatives and vitamin E), only fullerene exhibited high antioxidant capacity under all three oxidation conditions. Especially it showed high antioxidizing ability against active oxygen caused by ultraviolet radiation.

By the way, because fullerene has a unique antioxidation mechanism that is different from the reduction effect by hydrogen atom—as in the case of antioxidants such as vitamin C—its antioxidant capacity cannot be evaluated with the method such as DPPH assay and ORAC.