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Whitening/Brightening

Introduction

“Freckle” which is always cited as one of the top examples of skin trouble—why are freckles made?
It is said that the main reason is "Reactive Oxygen Species"(ROS). ROS is generated in the skin by, for example, exposure to UV light. Freckle will appear once exposed to a large amount of UV light, this exposure will be activated melanin (melanocyte).

Fullerene is effective for whitening by its strong anti oxidation capacity and scavenging free radicals which is the base factor of freckle.

Reference:
Figure: Working mechanism

Test of Fullerene’s whitening effect

Methods

Fullerene was added or not to human melanoma cells which were then exposed to UV light respectively. (UVA2J/cm2)

Results

After exposed to UV irradiation, the cells without the addition of fullerene produced a large amount of melanin. On the other hand, such the phenomenon was observed to be suppressed by the addition of fullerene.

*Data was provided by Prefectural University of Hiroshima.
Reference: Mio Murakami, Noritoshi Maeda, Cosme Tech Japan 3(2), 90-91 (2012).

Clinical Test

Methods

Cosmetic gel formulated with 1% Radical Sponge was applied to the entire face of 18 test subjects, twice a day (morning and evening). The conditions of their cheeks were observed with a spectrophotometer before the application, after 4 weeks from the start of application, and after 8 weeks from the start of application.

Results

By using this gel, the decrease in melanin index and whitening efficacy was observed.

Methods

Freckles on the left upper arm were made by eliminating 1.5 MED UVA+B. 0.005g Cream formulated with 1% Radical Sponge and without Radical Sponge was applied to these freckles of 18 test subjects, twice a day (morning and evening). The conditions of their upper arms were observed with a spctrophotometer. (Cream was applied one week before the elimination. The graph shows the average of 18 subjects and sets 1.00 as the first week of elimination.)

Results

The melanin index significantly decreased compared with the control.

By using the fullerene blended cosmetics for 8 weeks, the decrease in melanin index that is related to skin brightness was observed.

Reference: Mio Murakami, Noritoshi Maeda, Cosme Tech Japan 3(2), 90-91 (2012).